Gallery

PUBLICATIONS

*Mandl lab members are underlined

2024

Wortel IM, Postat J, Mihaylova M, Merino M, Bhagrath A, Harris M, Wouters L, Wiebke L, Parisi DR, Mandl JN, Textor J. (2024). "Cooperative motility emerges in crowds of T cells but not neutrophils." bioRxiv: 2024.2010.2021.618803.

Ham H, Jing H, Lamborn IT, Kober MM, Koval A, Berchiche YA, Anderson DE, Druey KM, Mandl JN, et al. (2024). "Germline mutations in a G protein identify signaling cross-talk in T cells." Science 385(6715): eadd8947. doi:10.1126/science.add8947

Shen C, Postat J, Cerf A, Merino M, Bhagrath A, Patel D, Luo VM, Abu-Thuraia A, Schneider C, Sharma A, Suh W.-K., Ehrlicher A, Côté J.-F., Mandl JN (2024). "DOCK8 regulates a mechanosensitive actin redistribution that maintains immune cell cohesion and protects the nucleus during migration." bioRxiv: 2024.2007.2026.605273.

Jamaleddine H, Rogers D, Perrault G, Patel D, Mandl JN, Khadra A. (2024) "Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity." PLoS Biol 22(2): e3002465. doi: 10.1371/journal.pbio.3002465

Luo VM, Shen C, Worme S, Bhagrath A, Simo-Cheyou E, Findlay S, Hébert S, Wai Lam Poon W, Aryanpour Z, Zhang T, Zahedi RP, Boulais J, Buchwald ZS, Borchers CH, Côté JF, Kleinman CL, Mandl JN, Orthwein A (2024). "The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2". Molecular and Cellular Biology, 44(1), 1-16. doi:10.1080/10985549.2023.2290434

2022-2023

Meli AP, Russell GA, Swaminathan S, Weichselbaum L, MacMahon CA, Pernet E, Karo-Atar D, Rogers D, Rochette A, Fontes G, Mandl JN, Divangahi M, Klein OD, Gregorieff A, Stäger S, King IL. (2023). "Bcl-6 expression by CD4(+) T cells determines concomitant immunity and host resistance across distinct parasitic infections." Mucosal Immunol 16(6): 801-816. doi: 10.1016/j.mucimm.2023.08.004

Textor J, Buytenhuijs F, Rogers D, Gauthier EM, Sultan S, Wortel IMN, Kalies K, Fähnrich A, Pagel R, Melichar HJ, Westermann J, Mandl JN. (2023) "Machine learning analysis of the T cell receptor repertoire identifies sequence features that predict self-reactivity." Cell Syst. 14(12): 1059-1073. doi: 10.1016/j.cels.2023.11.004

Mandl JN, Melichar HJ. (2023) "Revealing the identity of regulatory T-cell-suppressed self-reactive CD4⁺ T cells." Cell Mol Immunol 20(10): 1093–1094. doi: 10.1038/s41423-023-01021-0

McDowell SAC, Milette S, Doré S, Yu MW, Sorin M, Wilson L, Desharnais L, Cristea A, Varol O, Atallah A, Swaby A, Breton V, Arabzadeh A, Petrecca S, Loucif H, Bhagrath A, De Meo M, Lach KD, Issac MSM, Fiset B, Rayes RF, Mandl JN, Fritz JH, Fiset PO, Holt PR, Dannenberg AJ, Spicer JD, Walsh LA, Quail DF. (2023) "Obesity alters monocyte developmental trajectories to enhance metastasis." J Exp Med. 220(8). doi: 10.1084/jem.20220509

Shen C, Mulder E, Buitenwerf W, Postat J, Jansen A, Kox M, Mandl JN, Vrisekoop N. (2023). "Nuclear segmentation facilitates neutrophil migration". J. Cell Sci. 136, jcs260768. doi: 10.1242/jcs.260768

Parisi DR, Wiebke LE, Mandl JN, Textor J. (2023) "Flow rate resonance of actively deforming particles." Sci Rep 13(1), 9455. doi: 10.1038/s41598-023-36182-5

This S, Rogers D, Gauthier ÈM, Mandl JN, Melichar HJ. (2022) "What's self got to do with it: Sources of heterogeneity among naive T cells." Semin. Immunol. 65:101702. doi: 10.1016/j.smim.2022.101702

2020 - 2021

Rogers D, Sood A, Wang H, van Beek JJP, Rademaker TJ, Artusa P, Schneider C, Shen C, Wong DC, Bhagrath A, Lebel MÈ, Condotta SA, Richer MJ, Martins AJ, Tsang JS, Barreiro LB, François P, Langlais D, Melichar HJ, Textor J, Mandl JN. (2021) "Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential." Cell Rep. 37(9):110064. doi: 10.1016/j.celrep.2021.110064

Schneider C, Shen C, Gopal AA, Douglas T, Forestell B, Kauffman KD, Artusa P, Zhang Q, Freeman AF, Barber DL, King IL, Saleh M, Wiseman PW, Su HC, Mandl JN. (2020) "Migration-induced cell shattering due to DOCK8-deficiency causes a type-2 biased helper T cell response." (2020) Nat. Immunol. 21(12):1528-1539.

doi: 10.1038/s41590-020-0795-1

Olivier JF, Fodil N, Al Habyan S, Gopal AA, Artusa P, Mandl JN, McCaffrey L, Gros P. (2020) "CCDC88B is required for mobility and inflammatory functions of dendritic cells". J Leukoc Biol: 1-16.

doi: 10.1002/JLB.3A0420-386R

Wortel IMN, Kesmir C, de Boer RJ, Mandl JN, Textor J. (2020) "Is T cell Negative Selection a Learning Algorithm?" Cells 9(3): pii E690. doi: 10.3390/cells9030690

> For a unique read into the paper, check out Inge Wortel's blog post!

Gentile ME, Li Y, Robertson A, Shah K, Fontes G, Kaufmann E, Polese B, Khan N, Parisien M, Munter HM, Mandl JN, Diatchenko L, Divangahi M, King IL. (2020) "NK Cells Recruitment limits tissue damage during an enteric helminth infection". Mucosal Immunology 13(2): 357-370. doi: 10.1038/s41385-019-0231-8

2018 -2019

Sood A, Lebel MÈ, Fournier M, Rogers D, Mandl JN, Melichar HJ. (2019) "Differential interferongamma production potential among naive CD4+ T cells exists prior to antigen encounter". Immunology and Cell Biology 97(10): 931-940. doi: 10.1111/imcb.12287

Yuki, K.E., Marei, H., Fiskin, E., Eva, M.M., Gopal, A.A., Schwartzentruber, J.A., Majewski, J., Cellier, M., Mandl, J.N., Vidal, S.M., Malo, D., and Dikic, I. “CYRI1/FAM49B Negatively Regulates RAC1-driven Cytoskeletal Remodelling and Protects Against Bacterial Infection". Nat Microbiol 4(9): 1516-1531. doi: 10.1038/s41564-019-0484-8

Tong, A.A., Forestell, B., Murphy, D.V., Nair, A., Allen, F., Myers, J., Klauschen, F., Shen, C., Gopal, A.A., Huang, A.Y., Mandl, J.N. (2019) "Regulatory T cells differ from conventional CD4+ T cells in their recirculatory behavior and lymph node transit times." Immunol Cell Biol. doi: 10.1111/imcb.12276

Mandl, J.N., Schneider, C., Schneider, D.S., and Baker, M.L. (2018) “Going to bat(s) for studies of disease tolerance.” Frontiers in Immunology 9:2112. doi: 10.3389/fimmu.2018.02112

2016 -2017

Dong, M., Artusa, P., Kelly, S.A., Fournier, M., Baldwin, T.A., Mandl, J.N., and Melichar, H.J. (2017) “Alterations in the thymic selection threshold skew the self-reactivity of the T cell receptor repertoire in neonates.” Journal of Immunology. 199(3):965-973. doi: 10.4049/jimmunol.1602137

Vrisekoop, N., Artusa P., Monteiro, J.P., and Mandl, J.N. (2017) “Weakly self-reactive T cell clones can homeostatically expand when present at low numbers.” Eur J Immunol 47(1):68-73. doi: 10.1002/eji.201646540

Textor, J., Mandl, J.N., and de Boer, R.J. (2016) “The reticular cell network: a robust backbone for immune responses.” PLos Biology 14(10):e2000827

(Commentary). doi: 10.1371/journal.pbio.2000827

Lippens, C., Duraes, F. V., Guery, L., Dubrot, J., Brighouse, D., Lacroix, M., Magali, I., Aubry-Lachainaye, J., Reith, W., Mandl, J.N., and Hugues, S. (2016) “IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity.” Journal of Autoimmunity 75:39-49. doi: 10.1016/j.jaut.2016.07.004

2014 -2015

Mandl, J.N., and Feinberg, M.B. (2015) “Robust and sustained immune activation in human Ebola virus infection.” Proc. Natl. Acad. Sci. USA, 112(15):4518-9. (Commentary).

Mandl, J.N., Barreiro, L., Epstein, J., Daszak, P., Ahmed, R., Virgin, H., and Feinberg, M.B. (2015) “Reservoir host immune responses to emerging zoonotic viruses.” Cell, 160 (1-2):20-35.

Zhang, Q., Dove, C., Strauss-Albee, D., Garcia, J., Mandl, J.N., Grodick, R., Chandler-Brown, D., Jing, H., Kim, E., Lenardo, T.E., Matthews, H.F., Freeman, A.F., Cornall, R.J., Germain, R.N., Mueller, S.N., and Su, H. (2014) “DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.” Journal of Experimental Medicine, 211(13):2549-66.

Textor, J., Hendrickson, S.E., Mandl, J.N., von Andrian, U.H., Westermann, J., de Boer, R.J., and Beltman, J.B. (2014) “Random Migration and Signal Integration Promote Rapid and Robust T cell Recruitment.” PLoS Computational Biology 10(8): e1003752.

Vrisekoop, N., Monteiro, J.P., Mandl, J.N., and Germain, R.N. (2014) “Revisiting thymic positive selection and the mature T cell repertoire for antigen.” Immunity 41(2):181-190.

Mandl, J.N. and Germain, R.N. (2014) “Focusing in on T cell cross-reactivity.” Cell. 157(5): 1006-1008.

(Commentary).

Mandl, J.N., Torabi-Parizi, P., and Germain, R.N. (2014) “Visualization and dynamic analysis of host-pathogen interactions.” Curr. Opin. Immunol. 29:8-15.

Bouma, H.R., Mandl, J.N., Strijkstra, A.M., Boerema, A.S., Kok, J.W., van Dam, A., Ijzerman, A., Kroese, F.G., Henning, R.H. (2013) “5’AMP impacts lymphocyte recirculation through activation of A2B receptors.” J. Leukocyte Biology, 94(1):89-98.

2013 & earlier

Mandl, J.N., Monteiro, J.P., Vrisekoop, N., and Germain, R.N. (2013) “T cell positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.” Immunity 38(2):263-74.

Mandl, J.N., Liou, R., Klauschen, F., Vrisekoop, N., Monteiro, J.P., Yates, A.J., Huang, A.Y., and Germain, R.N. (2012) “Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4 and CD8 T cells.” Proc Natl Acad Sci USA 109(44):18036-41.

Meteyer, C.U., Barber, D., Mandl, J.N. (2012) “Pathology in euthermic bats with white nose syndrome suggests a natural manifestation of immune reconstitution inflammatory syndrome.” Virulence 3(7).

Lee, M., Mandl, J.N., Germain, R.N., and Yates, A.J. (2012) “The race for the prize – T cell trafficking strategies”. Blood 120(7):1432-8.

Mandl, J.N., Akondy, R., Lawson, B., Kozyr, N., Staprans, S.I., Ahmed, R., and Feinberg, M.B. (2011) “Distinctive TLR7 signalling, type I interferon production and attenuated innate and adaptive immune responses to yellow fever virus in a primate reservoir host.” J. Immunology 186(11):6406-16.

Vrisekoop, N., Mandl, J.N., and Germain, R.N. (2009) “Life and death as a T lymphocyte: from immune protection to HIV pathogenesis.” Journal of Biology 8(10):91

Mandl, J.N., Barry, A.P., Vanderford, T.H., Kozyr, N., Chavan, R., Klucking, S., Barrat, F.J., Coffman, R.L., Staprans, S.I., and Feinberg, M.B. (2008) “DIvergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.” Nature Medicine 14 (10): 1077–1087.